Effectiveness of the combinational treatment ofLaminaria japonicaandCistanche tubulosaextracts in hair growth
January 2015
in “Laboratory Animal Research”
TLDR Laminaria japonica and Cistanche tubulosa extracts combined may effectively promote hair growth.
The study from 2015 examined the hair growth-promoting effects of Laminaria japonica extract (LJE) and Cistanche tubulosa extract (CTE) on male C57BL/6 mice, comparing them to the effects of 3% Minoxidil. Over 21 days, the mice were treated with these substances, and the combination of LJE and CTE at specific doses (54 mg/kg LJE plus 162 mg/kg CTE) showed synergistic effects on hair regrowth, comparable to Minoxidil. This combination enhanced enzyme activities and growth factor levels associated with hair growth, such as ALP, y-GTP, EGF, and VEGF. Additionally, the extracts demonstrated anti-inflammatory properties by reducing inflammation in a mouse model. The study concluded that the oral treatment with LJE and CTE could be an effective approach to prevent hair loss and improve alopecia, potentially due to their anti-inflammatory activities.
View this study on synapse.koreamed.org →
Cited in this study
research New aspects of the treatment of alopecia areata
Personalized treatment plans are important for people with alopecia areata.
research Pathogenesis of androgenetic alopecia
Male pattern baldness involves three mechanisms and finasteride can help reverse it.
research KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models
KF19418 promotes hair growth similarly to minoxidil but is not better in live mice.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
research The Biology of Hair Follicles
Hair follicle biology advancements may lead to better hair growth disorder treatments.
research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia
Finasteride effectively treats male hair loss, improving growth and density.
research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy
Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
research Minoxidil Sulfate Is the Active Metabolite that Stimulates Hair Follicles
Minoxidil sulfate stimulates hair growth.
research Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.
Minoxidil sulfate relaxes muscle by increasing potassium flow, making it a unique muscle relaxer.
research Hypertrichosis due to minoxidil
Minoxidil can cause excessive hair growth.
research Hypertrichosis due to minoxidil
Minoxidil causes excessive hair growth in almost all patients.