Effect of Vitamin D Supplementation on Post-Covid-19 Manifestations in Menoufia University Hospitals: A Randomized Controlled Clinical Trial

The study, conducted on 111 post-COVID-19 patients at Menoufia University Hospital, aimed to evaluate the effect of vitamin-D supplementation on post-COVID-19 symptoms. The patients were randomly assigned to a 2-month supplementation regimen of either vitamin-D (2000 IU/tablet daily) or a placebo. The results showed that 75.7% of patients with insufficient vitamin-D levels experienced more than 3 post-COVID-19 symptoms. There was a significant negative correlation between the frequency of post-COVID-19 symptoms and vitamin-D levels (R=-0.505, P-value< 0.001). After the 2-month vitamin-D supplementation, there was a significant improvement in various symptoms such as fatigue, sleep disturbance, lack of concentration, cough, myalgia, arthralgia, and hair loss (P-value<0.001). The study concludes that there is a significant connection between vitamin-D deficiency and persistent post-COVID-19 symptoms, suggesting the beneficial role of vitamin-D in relieving these symptoms. It recommends routine assessment of vitamin-D levels in individuals with post-COVID-19 symptoms and vitamin-D supplementation in cases of deficiency.