The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma Lucidum on Inhibition of the Primary Tumor Metastasis

    January 2014 in “ Evidence-based Complementary and Alternative Medicine ”
    Shiu‐Nan Chen, Ching-Sheng Chang, Ming-Hsin Hung, Sherwin Chen, William Wang, Cheng-Jeng Tai, Chung‐Lun Lu
    TLDR Mushroom beta-glucans from Ganoderma lucidum can reduce tumor size and metastasis in cancer.
    The study investigated the effects of mushroom beta-glucans (MBGS) from Ganoderma lucidum on tumor metastasis in mice with Lewis lung carcinoma. Results showed that MBGS significantly reduced primary tumor size, decreased metastasis rates, and enhanced NK cell-mediated cytotoxicity. Mice treated with both MBGS and radiation therapy had the lowest incidence of metastasis (20%) and the fewest metastatic tumor nodules (1 nodule on average). Additionally, MBGS treatments mitigated hair loss and external wounds associated with tumor growth. The findings suggested that MBGS could be a beneficial adjunct in cancer therapy.
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