TLDR Metformin improved insulin resistance and BMI in overweight Taiwanese women with PCOS, and a 2-hour insulin test may be a good screening tool.
The study evaluated the effects of metformin on 114 Taiwanese women with polycystic ovary syndrome (PCOS), focusing on insulin resistance (IR) and body mass index (BMI). Metformin significantly improved BMI in overweight patients and reduced 2-hour insulin levels, with greater improvement observed in IR patients. Diagnostic measures for IR showed varying sensitivity and specificity, with the 2-hour postload insulin level being proposed as a convenient screening tool. The study also noted that extended-release (XR) metformin may improve treatment adherence. The results suggest that metformin is effective for improving IR and BMI in overweight and IR Taiwanese women with PCOS, and the 2-hour postload insulin level from an oral glucose tolerance test (OGTT) could be a practical method for IR screening in this population. However, the study had limitations, including the absence of a comparison group, and further research is needed to confirm these findings in different populations and establish a specific cutoff for diagnosing IR in PCOS women.View this study on doi.org →
Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.
The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.
Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.
PCOS is common among Chinese women of reproductive age and linked to serious metabolic and reproductive issues, especially in obese women.
Obesity is a major risk factor for insulin resistance in Taiwanese women with PCOS, which is also an independent risk factor for metabolic syndrome.
Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
Metformin improved insulin resistance and BMI in overweight Taiwanese women with PCOS, and a 2-hour insulin test may be a good screening tool.