Histological Investigation of the Effect of Adipose-Derived Stromal Vascular Fraction Cells on Androgenic Alopecia in Rat Model

January 2026 in “ Minia Journal of Medical Research ”

Medhat Atta Salah, Abdel Hamid Sayed AboBakr, Mohamed Ahmed Desouky, mary Malak Reyad, Manar Fouli Gaber, Eman A. Abd El‐Meguid

adipose-derived stromal vascular fraction cells androgenic alopecia testosterone epidermal thickness hair follicle structure dermal architecture SVF cells

TLDR SVF cell therapy may help regenerate hair in androgenic alopecia.

This study investigated the effects of adipose-derived stromal vascular fraction (SVF) cells on androgenic alopecia in a rat model. Sixty male albino rats were divided into four groups, with one group receiving SVF cell therapy after testosterone-induced alopecia. The results showed that the SVF therapy group exhibited significant restoration of epidermal thickness, hair follicle structure, and dermal architecture, closely resembling the normal pattern of the control group. The findings suggest that SVF cell therapy may play a potential role in regenerating hair follicles affected by androgenic alopecia.

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