Editorial Comment

October 2013 in “ Urology ”

Darius J. Unwala

dutasteride finasteride 5 alpha reductase inhibitor Avodart Propecia

TLDR More men are using medication for benign prostatic hyperplasia, influenced by marketing and FDA approvals.

The editorial discussed the increasing trend in using medication to manage benign prostatic hyperplasia (BPH) in men, highlighting several key factors contributing to this shift. The FDA approvals of tamsulosin and dutasteride, along with significant studies like the Medical Therapy of Prostatic Symptoms trial and research by Kaplan et al., were pivotal in this trend. Despite no proven superiority of dutasteride over finasteride, it became the most commonly prescribed 5 alpha reductase inhibitor, influenced by FDA's approval of direct-to-consumer marketing. This shift raised concerns about adherence to evidence-based medicine.

View this study on goldjournal.net →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations , December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

Related Community Posts Join

6 / 1000+ results

community Hair Loss Drugs Ranked in Order of Efficacy

in Research/Science 67 upvotes 2 years ago

Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

community Bryan Johnson shares information on his hair loss stack

in Research/Science 267 upvotes 1 year ago

Bryan Johnson uses topical dutasteride, minoxidil, and microneedling for hair loss. Users discuss treatment effectiveness and side effects, debating topical versus oral dutasteride efficacy.

community M30, month 5 of dutasteride and minoxidil

in Progress Pictures 252 upvotes 2 months ago

A 30-year-old male experienced significant hair regrowth after five months of using topical minoxidil (5% foam) and oral dutasteride (0.5 mg daily). The user reported no side effects and was grateful for the progress, despite the rapid gains slowing down.

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 16 upvotes 5 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

community Logical reason as to why people don't get results on dutasteride?

in Finasteride/Dutasteride 25 upvotes 4 months ago

Many users report better results with finasteride than dutasteride for hair loss, despite studies suggesting otherwise. Some suggest that dutasteride's effectiveness may depend on the delivery method, such as using lipids for absorption.

Related Research

2 / 2 results

research Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride

August 2016 in “Journal of Investigative Dermatology”

research The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice

April 2013 in “The FASEB Journal”

Dutasteride showed some prevention of prostate issues but also had limitations, especially with high-grade tumors.