Evaluation of E-Cadherin and Hydrogen Peroxide in Skin of Patients with Vitiligo

October 2021 in “ QJM: An International Journal of Medicine ”

Marwa Abdallah, Mona A. Ahmed, Manal L. Louka, Christine K. Gobrial, Alaa Abdel-Hakim Abdel-Magid

E-cadherin Hydrogen Peroxide oxidative stress keratinocytes melanocytes non-segmental vitiligo cell-to-cell adhesion pigmentary system H2O2

TLDR Vitiligo patients have higher hydrogen peroxide levels and lower E-cadherin, affecting skin cell adhesion and pigmentation.

The study "Evaluation of E- cadherin and Hydrogen Peroxide in Skin of Patients with Vitiligo" conducted by Marwa M Abdel-Rahim Abdallah et al. involved 20 subjects divided into two groups: 10 patients with non-segmental vitiligo and 10 non-vitiliginous controls. The study found that Hydrogen Peroxide (H2O2) levels were increased in non-segmental vitiligo patients compared to healthy individuals, suggesting oxidative stress in vitiligo patients. Additionally, E-cadherin levels were significantly decreased in vitiligo skin compared to normal skin. The study concluded that vitiligo is not only confined to melanocytes but also affects keratinocytes, leading to pathological changes in vitiliginous lesions. This includes a loss of cell-to-cell adhesion between keratinocytes and melanocytes and between keratinocytes themselves, which may affect the skin's pigmentary system.

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