Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men

    April 2024 in “ Journal of Clinical Psychopharmacology ”
    Jonathan Covault, Howard Tennen, Richard Feinn
    Studysummary In this study, dutasteride 1 mg daily reduced heavy drinking days and drinks per week among treatment-seeking men, particularly benefiting those with high baseline drinking to cope motives.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment Psychopharmacology · 2014
    2. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011
    3. Inhibition of 5α-Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice Alcoholism Clinical and Experimental Research · 2008
    4. Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids Alcohol · 2005
    5. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    6. Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism European journal of endocrinology · 1999
    7. A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1995

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