Does Fat Get You Skinny?

The document discussed the evolving understanding of subcutaneous fat, particularly its role in epidermal biology and wound healing. It highlighted the concept of 'dermal white adipose tissue' (DWAT) as a distinct unit influencing epidermal homeostasis. Studies in animal models and human skin equivalents suggested that adipose tissue-derived signals could promote epidermal cell proliferation and differentiation, although the exact mechanisms remained unclear. The role of adipose-derived mesenchymal stromal cells (ASCs) and their conditioned media (ASC-CM) in keratinocyte differentiation was explored, with miR-24 identified as a potential mediator. However, the physiological significance and specific adipose-derived factors involved were not fully understood, indicating a need for further research to clarify these complex interactions and their implications for skin health and repair.