Studying the Disease Activity and the Degree of Internal Organ Damage in Systemic Lupus Erythematosus Patients in the Kazakh Population

The study investigated the relationship between disease activity and internal organ damage in 30 Kazakh women with systemic lupus erythematosus (SLE), with an average age of 36.33 years and an average disease duration of 5 years. The SELENA-SLEDAI scale showed that 10% of patients had low activity, 50% moderate, and 40% high, with common symptoms including arthritis (46.7%), myositis (56.7%), skin rashes (50%), mucosal ulcers (33.3%), and alopecia (30%). The SLICC/ACR damage index indicated low damage in 6.7% of patients, medium in 60%, and high in 30%, with frequent issues being vision changes and cognitive impairment (36.7%), and peripheral neuropathy (30%). A strong correlation (rρ=0.701, p<0.0001) was found between disease activity and organ damage, and a moderate correlation with disease duration (SELENA-SLEDAI: rρ=0.619, p<0.0001; SLICC/ACR: rρ=0.592, p=0.001), suggesting that both SELENA-SLEDAI and SLICC/ACR are reliable indicators of cumulative disease activity and damage.