Relationship of Dietary Intake of Omega-3 and Omega-6 Fatty Acids with Risk of Prostate Cancer Development: A Meta-Analysis of Prospective Studies and Review of Literature

The document reports on a case-control study involving 709 men, which found that early onset of androgenetic alopecia (AA) was significantly linked to an increased risk of prostate cancer (CaP). Among the participants, 312 were healthy controls, 167 had CaP, and 229 had a negative prostate biopsy. The study specifically noted that frontal balding was associated with a higher risk of CaP (p=0.004), and overall balding was correlated with more than a two-fold increase in the risk of high-grade disease (p<0.07). Despite these findings, the authors emphasized the need for further research with a larger sample size to confirm the results and to explore the underlying mechanisms connecting AA, androgens, and CaP. The research received funding from various sources, including the Department of Veterans Affairs and the Department of Defense.