Description of the Intrafollicular Delivery of Large Molecular Weight Molecules to Follicles of Human Scalp Skin In Vitro

September 1997 in “ Journal of Pharmaceutical Sciences ”

Linda M. Lieb, Andrew P. Liimatta, R. Nick Bryan, Bob D. Brown, Gerald G. Krueger

intrafollicular delivery human scalp follicles cationic lipid-based formulations oligonucleotides internal root sheath external root sheath dextrans hair shaft hair bulbs

TLDR Properly formulated large molecules can reach active levels at the hair bulb.

The study investigated the intrafollicular delivery of large molecules to human scalp follicles in vitro, focusing on factors like size, charge, and formulation. It found that cationic lipid-based formulations enhanced the delivery of oligonucleotides within the follicle, directing permeation along the junction of the internal and external root sheath. Lower molecular weight dextrans permeated all follicle components, while higher molecular weight dextrans were confined near the hair shaft. Approximately 0.5% of the applied dose reached the hair bulbs and deeper skin layers within 24 hours. The study concluded that large molecular weight agents, when properly formulated, could achieve pharmacologically active concentrations at the hair bulb.

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