Dercum Disease: Exploratory Therapeutic Approaches in the Absence of Standardized Medical Treatment—A Single Center Case Series

    April 2026 in “ Life ”
    Alessandro Magnatta, Alice Verdelli, Virginia Corti, Luca Sanna, Manfredi Magliulo, Valentina Ruffo di Calabria, Elisabetta Magnaterra, Elena Biancamaria Mariotti, Simone Landini, Rachel Daher, Irene Bonanni, Marta Donati, Francesca Gorini, Alessio Coi, Ilaria Di Donato, Cinzia Pupilli, Marzia Caproni
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    Studysummary In this retrospective case series, therapeutic responses to immunomodulatory and incretin-based therapies for Dercum's disease showed considerable individual variation, suggesting these treatments might be exploratory options when surgery isn't feasible, though further controlled studies are needed for definitive conclusions.
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    This study investigates therapeutic approaches for Dercum Disease (DD), a rare condition with no standardized treatment, through a single-center case series involving 5 female patients aged 44-65. The research evaluated treatments such as methotrexate, infliximab, GLP-1 receptor agonists (semaglutide and tirzepatide), and surgical interventions like lipectomy and liposuction. Results showed variable improvements in pain and quality of life, with some patients experiencing significant benefits, particularly with GLP-1 RAs aiding in weight reduction and pain relief. However, responses were inconsistent, and surgical options often led to recurrence. Adverse events were generally manageable. The study underscores the need for individualized treatment strategies and further research to establish effective long-term management for DD.
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