Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia

    June 2012 in “ International Journal of Molecular Medicine ”
    Naoki Nanashima, Koichi Ito, Takashi Ishikawa, Manabu Nakano, Toshiya Nakamura
    TLDR Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.
    The study investigated the effects of radiation-induced acute alopecia in 6-week-old male C57/BL6 mice exposed to 6 Gy of X-ray irradiation. It was found that while the major hair keratins (Krt81, Krt83, Krt86) remained unchanged, there was a decrease in cytokeratin Krt15 and CD34, markers of hair follicle stem cells, in alopecic mice. Conversely, cytokeratin Krt5, a marker for basal and undifferentiated keratinocytes, increased in the epidermis. These results indicated that radiation damaged hair stem cells and affected keratinocyte differentiation, suggesting that Krt5 could serve as a novel biological marker for acute radiation symptoms, alongside the traditional chromosomal aberration evaluation.
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