Cyclosporine A-Induced Intracranial Thrombotic Complications: Systematic Review and Case Report

    February 2021 in “ Frontiers in Neurology ”
    Siying Song, Zhongao Wang, Yuchuan Ding, Xunming Ji, Ran Meng
    TLDR Cyclosporine-A can cause serious blood clots in the brain, so patients need careful monitoring.
    The document reviewed cases and literature on cyclosporine-A (CsA)-induced intracranial thrombotic complications, particularly cerebral venous thrombosis (CVT). It highlighted that CsA, an immunosuppressive drug, was associated with increased thrombotic risks, especially in patients with aplastic anemia (AA) and those undergoing renal transplantation. The review identified 79 articles involving 706 patients and found that CsA-induced thrombosis could affect arteries, veins, and capillaries, with renal vascular damage being most common. The study emphasized the need for careful monitoring of thrombotic events in patients treated with CsA and called for further research to understand its prothrombotic effects.
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