Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness
December 2020
in “
Molecules
”
New to Curcumin? There is a guide in the encyclopedia. Read the guide → Studysummary This study reported that a newly formulated Curcumin-loaded proniosome, named F5, exhibited enhanced antiviral efficacy, stability, and safety when compared to Curcumin alone, and improved the therapeutic performance of Acyclovir by reducing its effective dose against Herpes simplex virus.
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The study developed a Curcumin-loaded proniosomal delivery system to enhance its antiviral effectiveness against Herpes simplex type 1 virus (HSV-1). Using a 32 factorial design, the researchers optimized a formula (F5) that showed improved entrapment efficiency and drug release. F5 demonstrated significantly higher antiviral activity, reducing viral plaques by 90% compared to 75% for Curcumin dispersion at 30 μM concentration. It also enhanced the safety and efficacy of Acyclovir by increasing its selectivity index from 13.1 to 64.5. The findings suggested that Curcumin-loaded proniosomes could serve as promising carriers for safe and effective antiviral treatments.
