Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

    December 2020 in “ Molecules ”
    Farid A. Badria, Abdelaziz E. Abdelaziz, Amira H. Hassan, Abdullah A. Elgazar, Eman A. Mazyed
    TLDR A new delivery system makes Curcumin more effective and safer against viruses.
    The study developed a proniosome-based nanodelivery system for Curcumin to enhance its antiviral efficacy and stability. Using a 32 factorial design, the optimized formula (F5) showed an entrapment efficiency of 89.94% and a 12-hour drug release of 70.89%. F5 demonstrated improved stability and antiviral activity against Herpes simplex virus compared to standard Curcumin, enhancing the safety and reducing the effective dose of Acyclovir. This suggests that proniosomes could serve as promising carriers for Curcumin as a safe and effective antiviral agent.
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