Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

    December 2020 in “ Molecules ”
    Farid A. Badria, Abdelaziz E. Abdelaziz, Amira H. Hassan, Abdullah A. Elgazar, Eman A. Mazyed
    TLDR A new delivery system makes Curcumin more effective and safer against viruses.
    The study developed a Curcumin-loaded proniosomal delivery system to enhance its antiviral effectiveness against Herpes simplex type 1 virus (HSV-1). Using a 32 factorial design, the researchers optimized a formula (F5) that showed improved entrapment efficiency and drug release. F5 demonstrated significantly higher antiviral activity, reducing viral plaques by 90% compared to 75% for Curcumin dispersion at 30 μM concentration. It also enhanced the safety and efficacy of Acyclovir by increasing its selectivity index from 13.1 to 64.5. The findings suggested that Curcumin-loaded proniosomes could serve as promising carriers for safe and effective antiviral treatments.
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