Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline
November 2006
in “The Journal of Clinical Endocrinology and Metabolism”
TLDR Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.
The Androgen Excess Society Task Force on PCOS recommended that Polycystic Ovary Syndrome should be primarily considered a disorder of androgen excess, and that the definition of PCOS should emphasize hyperandrogenism as a central feature. They proposed modifications to the 1990 NIH criteria for PCOS, informed by discussions from the 2003 Rotterdam conference. The task force identified nine different PCOS phenotypes based on various combinations of ovulatory dysfunction, hirsutism, hyperandrogenemia, and polycystic ovaries. They found strong evidence of increased metabolic dysfunction risk in women with phenotypes showing hirsutism and/or hyperandrogenemia. The recommendations were based on a systematic review of literature, prioritizing studies with over 100 subjects, and a consensus process with international experts. The task force noted that the definition of PCOS might change with new research and that women with PCOS symptoms should be treated even if they do not meet the full diagnostic criteria.
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Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.
research Health Care-Related Economic Burden of the Polycystic Ovary Syndrome during the Reproductive Life Span
Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.
research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.
research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
research Prevalence of polycystic ovaries in women with androgenic alopecia
Women with androgenic alopecia are more likely to have polycystic ovaries and higher androgen levels, which may indicate PCOS.
research A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia
Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.