Could Vaccination Against COVID-19 Trigger Immune-Mediated Inflammatory Diseases?

    August 2024 in “ Journal of Clinical Medicine ”
    Aikaterini Ι. Liakou, Andreas G. Tsantes, Eleni Routsi, Efthymia Agiasofitou, Magdalini Kalamata, Evangelia‐Konstantina Bompou, Konstantina A. Tsante, Soultana Vladeni, Eleni Chatzidimitriou, Ourania Kotsafti, George Samonis, Stefanos Bonovas, Alexander I. Stratigos
    TLDR COVID-19 mRNA vaccines may increase the risk of flare-ups in certain inflammatory diseases.
    The article investigates the potential link between COVID-19 vaccination, particularly mRNA vaccines, and the exacerbation or onset of immune-mediated inflammatory diseases (IMIDs) such as psoriasis, hidradenitis suppurativa, atopic dermatitis, lichen planus, and alopecia areata. It reports that patients with hidradenitis suppurativa who received mRNA vaccines were 3.5 times more likely to experience flares compared to those who received non-mRNA vaccines. Similar associations were observed with other diseases, suggesting a possible connection between mRNA COVID-19 vaccines and these conditions. However, the authors stress the need for further research in larger populations to confirm these findings, while emphasizing that the benefits of vaccination in preventing severe COVID-19 outweigh these potential risks.
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