Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

    May 2000 in “ Journal of Investigative Dermatology ”
    Li-Chun Wang, Zhongying Liu, Laure Gambardella … Linda C. Burkly
    Studysummary This study demonstrated that blocking the Sonic hedgehog signaling pathway in mice led to reversible inhibition of body coat hair morphogenesis, while whisker development was unaffected.
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    Research cited in this study 3

    1. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    2. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    3. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998