Common Pathologic Pathways: A Single Prescription Dream?
October 2012
in “
Medical Hypotheses
”
TLDR The conclusion suggests that treatments targeting root causes of chronic diseases may be developed by focusing on gene expression and lifestyle factors.
The document from 2012 discusses the possibility of a unified treatment approach for chronic diseases, which account for 70% of deaths in Americans, by targeting common pathophysiological mechanisms such as inflammation and oxidative stress. It notes that chronic diseases like heart disease, cancer, and stroke are linked to nutrition and lifestyle, and that dietary guidelines are similar across various health associations due to epidemiological evidence. The paper highlights the imbalance in the ratio of omega-6 to omega-3 fatty acids in Western diets and suggests that correcting this could help modulate disease processes. It also mentions metformin as an example of a drug with multiple protective effects against chronic diseases. The conclusion points to the potential of developing treatments that address the root causes of chronic diseases by understanding gene expression and post-translational modifications.
