Collapse in João Pessoa Strengthens the Memorial of Paraiban Architecture

The document discussed the use of targeted drugs in cancer management, highlighting their ability to block specific cancer cell processes with better tolerance compared to conventional chemotherapy. However, these drugs often caused cutaneous reactions due to the presence of target molecules in the skin. Tyrosine kinase inhibitors were associated with edema and macular rash, while epidermal growth factor receptor inhibitors led to PRIDE syndrome, which included symptoms like papulopustular rash and hair changes. Vismodegib was linked to muscle spasms and alopecia, and other drugs like bortezomib, sunitinib, and sorafenib caused various skin reactions. New melanoma therapies, such as ipilimumab and BRAF inhibitors, resulted in immune-related skin issues and increased cancer risks. Dermatologists needed to be aware of these reactions to manage cancer patients effectively.