Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks

December 2022 in “ Genes ”

Guangyao Meng, Qi Bao, Xiaoming Ma, Min Chu, Chun Huang, Xian Guo, Chunnian Liang, Ping Yan

copy number variation CNV CNV regions CNVR hair growth hair-follicle development ASTN2 ATM COL22A1

TLDR CNVs influence hair length in Tianzhu white yaks.

This study conducted a genome-wide analysis of copy number variation (CNV) in 10 long-haired and 10 normal-haired Tianzhu white yaks, identifying 110,268 CNVs and 2,006 CNV regions (CNVRs). The research highlighted 80 differential CNVR-harbored genes, with some linked to hair growth and hair-follicle development, such as ASTN2, ATM, and COL22A1. These findings offer new insights into the genetic basis of hair length variation in Tianzhu white yaks, emphasizing the role of CNVs in phenotypic diversity.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak

research Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak

7 citations , March 2022 in “Frontiers in Genetics”

The research found specific genes that may cause longer hair in Tianzhu White Yak.

research Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

13 citations , January 2021 in “Histochemistry and Cell Biology”

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

14 citations , October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research Skin-Specific Regulation of SREBP Processing and Lipid Biosynthesis by Glycerol Kinase 5

18 citations , June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

A gene called Gk5 controls lipid production in the skin and affects hair growth.

research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

40 citations , March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

58 citations , October 2016 in “Journal of Investigative Dermatology”

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

27 citations , February 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

research Androgen Actions on the Human Hair Follicle: Perspectives

115 citations , September 2012 in “Experimental Dermatology”

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

research A Novel Marker of Tissue Junctions, Collagen XXII

226 citations , May 2004 in “Journal of Biological Chemistry”

Collagen XXII is a marker for tissue junctions, aiding in structural integrity and found in muscles, heart, skin, and arthritic joints.

Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations , October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Similar Research

5 / 1000+ results

research A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

November 2019

The study found genetic variations in sheep linked to traits like milk production, growth, and health.

research A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

60 citations , January 2021 in “BMC Genomics”

The study mapped genetic variations in sheep, linking them to traits like milk production and growth.

research Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

3 citations , April 2023 in “Veterinary sciences”

Researchers found genes that may explain why some pigs grow winter hair, which could help breed cold-resistant pigs.

research Copy Number Variation Regions in Nellore Cattle: Evidence of Environmental Adaptation

21 citations , November 2017 in “Livestock science”

Nellore cattle have genetic variations linked to their adaptation to tropical environments.

research Selection Signatures for Fiber Production in Commercial Species: A Review

5 citations , November 2022 in “Animal Genetics”

Genomic research can help improve the quality and production of natural fibers in animals.

Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks

Research cited in this study

research Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak

research Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Skin-Specific Regulation of SREBP Processing and Lipid Biosynthesis by Glycerol Kinase 5

research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

research Androgen Actions on the Human Hair Follicle: Perspectives

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research A Novel Marker of Tissue Junctions, Collagen XXII

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

Related Community Posts Join

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

community All in restoration Hair transplant from Dr Serkan in Turkey + topical fin/min Viviscal,biotin,sulfate free shampoo and Nizoral…very happy with results

community Does it work? Maneup GHK-Cu hair growth serum

community Potential ( but not yet confirmed ) pp405 leak through korean media.

community I built a free Al-powered hair transplant simulator for the community, would love your feedback!

community How does low level laser therapy?

Similar Research

research A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

research A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

research Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

research Copy Number Variation Regions in Nellore Cattle: Evidence of Environmental Adaptation

research Selection Signatures for Fiber Production in Commercial Species: A Review