Data Sheet 1: The Clinical Features, Muscle Pathology, and Role of Autophagy in Anti-Ku-Positive Patients

This study investigated the clinical and muscle histological characteristics of 6 anti-Ku-positive patients, revealing a predominant myositis pattern with necrotizing fibers and vacuolar changes. Extramuscular symptoms included hair loss, skin rash, and interstitial lung disease, with systemic sclerosis being the most common coexisting connective tissue disease. Muscle weakness was generally symmetrical and proximal, with some distal and axial involvement. Autophagy was identified as a key mechanism in the pathogenesis, with significant differences in p62 levels between anti-Ku and IMNM groups, and higher expression of LAMP2 and LC3 in anti-Ku-positive patients.