The Hair Loss Encyclopedia

Clinical Analysis of 83 Cases of Severe Alopecia Areata

January 2009 in “ Beijing Medical Journal ”

Lin Lin

alopecia areata atopy nail changes autoimmune diseases vitiligo thyroid disorders stressful events combined therapy oral corticosteroids topical corticosteroids minoxidil injection site pain facial hair thickening Rogaine

TLDR Combined therapy effectively improved severe alopecia areata in all patients after 6 months.

The study analyzed 83 cases of severe alopecia areata, with patients averaging 27 years old and a disease course of 7.6 months. A significant portion of patients (56.6%) were ≤16 years old, and 19.3% had a family history of alopecia areata. Atopy was present in 32.5% of cases, and 25.3% had nail changes. Autoimmune diseases were found in 14.4% of patients, with vitiligo and thyroid disorders each in 6% of cases. Stressful events preceded hair loss in 22.9% of patients. Combined therapy, including oral and topical corticosteroids and minoxidil, led to improvement in all patients after 6 months, despite some side effects like injection site pain (70.1%) and facial hair thickening (25.3%). The study concluded that combined therapy was effective, aligning with previous research despite some differences in family history and atopy.

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