Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

    July 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Tsun‐Hsien Hsiao, Chia-Hong Chou, Yi‐Lung Chen, Po‐Hsiang Wang, Guo-Jie Brandon-Mong, Tzong‐Huei Lee, Tien-Yu Wu, Po-Ting Li, Chenwei Li, Yi-Li Lai, Yu-Lin Tseng, Chao-Jen Shih, Mei‐Jou Chen, Yin‐Ru Chiang
    TLDR Certain gut bacteria can lower androgen levels in male mice.
    The study investigated the role of Thauera sp. strain GDN1, a betaproteobacterium, in regulating androgen levels in male mice. By administering this strain to C57BL/6J mice, researchers observed a significant reduction of approximately 50% in serum androgen levels. The study revealed that these bacteria could catabolize androgens aerobically and anaerobically in the gut, using them as a carbon source. This process was confirmed through genetic and biochemical analyses, which showed differential expression of androgen catabolic genes in the ileum and caecum. The findings suggested the potential of using androgen-catabolizing bacteria like Thauera sp. strain GDN1 as probiotics to treat conditions associated with high androgen levels, such as hyperandrogenism.
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