Cellular Plasticity in Cutaneous Wound Healing

The document discussed cellular plasticity in cutaneous wound healing, highlighting the ability of cells to change their fate in response to various influences. It described the wound healing process as involving inflammation, proliferation, and tissue remodeling, with contributions from soluble mediators, blood cells, extracellular matrix, and parenchymal cells. The review focused on how mature differentiated cells could dedifferentiate to a progenitor-like state or transdifferentiate into different lineages, and how some stem/progenitor cells could undergo transdetermination to aid in wound repair. The aim was to explore these mechanisms to enhance regenerative medicine.