Cell Proteomic Footprinting: Advances in the Quality of Cellular and Cell-Derived Cancer Vaccines

The article discusses cell proteomic footprinting, a proteomics technology that enhances the quality control and authentication of cellular cancer vaccines and other cell-based immunotherapeutics by analyzing the molecular phenotype of cells. This technology addresses the variability in antigenic profiles caused by factors like cell isolation, cultivation, and storage, which affect the therapeutic properties of cells. By providing protocols, footprint processing details, and program source code, the paper aims to facilitate the rapid adoption of cell proteomic footprinting in the development and manufacturing of cell-based therapies.