Central Centrifugal Cicatricial Alopecia (CCCA) Under the Scope: Histological Similarities Between CCCA and Lichen Planopilaris

September 2017 in “ The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings ”

Ariana Eginli, Erin Landis, Amy J. McMichael

Central Centrifugal Cicatricial Alopecia CCCA lichen planopilaris hair loss inner root sheath degeneration hair shaft migration outer root sheath perifollicular infiltrate fibrosis

TLDR CCCA and lichen planopilaris have similar histological features, making them hard to distinguish.

The document discussed Central Centrifugal Cicatricial Alopecia (CCCA), a form of hair loss prevalent among African-American women, often linked to genetic factors and haircare practices. Histologically, CCCA is marked by premature inner root sheath degeneration and hair shaft migration through the outer root sheath, with perifollicular infiltrate and fibrosis. A case of a 16-year-old African-American female with a 4-year history of hair loss, diagnosed with CCCA, revealed histological similarities to lichen planopilaris upon repeat biopsy. This case underscored that CCCA and lichen planopilaris might be histologically indistinguishable in African-American patients.

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