Cardiovascular Risk in Women with Premature Ovarian Insufficiency Compared to Premenopausal Women at Middle Age

The document presents a cross-sectional case-control study comparing cardiovascular disease (CVD) risk profiles between 83 women with premature ovarian insufficiency (POI) and 266 premenopausal controls, all at middle age. The study measured various health indicators, including blood pressure, BMI, waist circumference, and levels of different hormones and proteins. The results showed that women with POI had higher waist circumference, CRP, and free T4 levels, but lower NT-proBNP, E2, T, and androstenedione concentrations compared to controls. There was also a trend toward increased hypertension and decreased kidney function in women with POI. However, there were no signs of increased subclinical atherosclerosis in women with POI. The study concluded that women with POI exhibited an unfavorable cardiovascular risk profile, but additional research is needed to identify specific long-term CVD risk determinants in this population.