Cell Adhesion Molecules in Inflammatory and Neoplastic Skin Diseases

May 1993 in “ Journal of the European Academy of Dermatology and Venereology ”

M. Cagnoni, Ilaria Ghersetich, Torello Lotti

cell adhesion molecules CAMs ELAM-1 ICAM-1 LFA-1 alopecia areata lichen planus psoriasis

TLDR Cell adhesion molecules are important in the development of certain skin diseases.

The document reviewed the role of cell adhesion molecules (CAMs) in inflammatory and neoplastic skin diseases. CAMs, which include integrins, the immunoglobulin-gene family, cadherins, and lectin-like CAMs, were found to be significantly upregulated in various skin conditions such as alopecia areata, lichen planus, and psoriasis. The study highlighted that specific CAMs like ELAM-1, ICAM-1, and LFA-1 are predominantly involved in the pathogenesis of these diseases. Understanding the interaction mechanisms of CAMs has provided insights into their role in disease development and may aid in the diagnosis and treatment of these skin pathologies.

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Cell Adhesion Molecules in Inflammatory and Neoplastic Skin Diseases

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