Cell Adhesion Molecules in Inflammatory and Neoplastic Skin Diseases

    May 1993 in “ Journal of the European Academy of Dermatology and Venereology ”
    M. Cagnoni, Ilaria Ghersetich, Torello Lotti
    TLDR Cell adhesion molecules are important in the development of certain skin diseases.
    Cell adhesion molecules (CAMs) were found to play a significant role in the interaction of lymphocytes with various skin cells in both inflammatory and neoplastic skin diseases. The study highlighted an increased expression of CAMs, particularly ELAM-1, ICAM-1, and LFA-1, in conditions such as alopecia areata, lichen planus, and psoriasis compared to normal skin. This suggested that these molecules were crucial in the pathogenesis of these diseases. Understanding these interactions could aid in diagnosing and potentially treating various skin pathologies.
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