Optimizing Burn Injury Care: A Comparative Network Meta-Analysis of Skin Grafts' Efficacy

    February 2025 in “ Jurnal Kedokteran Brawijaya
    Imke Maria Del Rosario Puling, Nyoman Deva Pramana Giri, Teresa Almadita, Jane Limantara, Arviansyah Arviansyah
    TLDR Autologous skin cell transplantation speeds up healing and xenografts improve skin color in burn care.
    This study conducted a network meta-analysis of 7 articles to evaluate the efficacy of different skin grafts in burn injury care, focusing on reepithelialization time and repigmentation rate. It found that device-facilitated autologous skin cell transplantation significantly increased reepithelialization rates (OR=5.21), while xenografts had the highest repigmentation rate at 87.50%. The study suggests that device-facilitated autologous skin cell transplantation holds promise for clinical practice due to its high efficacy and minimal repigmentation. Quality assessment indicated that 6 studies were low-risk and 1 was moderate-risk of bias.
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