Brain–Skin Connection: The Contemporary Perspective Through Neuroendocrinology

January 2020 in “ Turkish Journal of Dermatology ”

Ayşenur Botsalı, Osman Köse

neuroendocrinology CRH ACTH cortisol stress hair diseases skin cells neuroendocrinologic molecules corticotropin-releasing hormone adrenocorticotropic hormone

TLDR Stress can affect skin and hair health through hormones.

This review highlighted the connection between the brain and skin through neuroendocrinology, focusing on the effects of neuroendocrinologic molecules on the skin and hair. It emphasized the role of the CRH–ACTH–cortisol axis, which is related to stress and is fully functional in the skin. The review suggested that this axis might explain the link between psychological stress and skin and hair diseases, indicating that stress could directly impact skin and hair health through neuroendocrinologic pathways.

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Research cited in this study

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research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

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research Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin

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