A Novel Bioactive Polymer Scaffold of Adipose-Derived Stem Cells Combining With Decellularized Extracellular Matrix in Tissue Engineering

The document discusses the development of AcD scaffolds, which combine adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) to enhance tissue repair and regeneration. These scaffolds improve biocompatibility, mechanical properties, and bioactivity, promoting angiogenesis, tissue integration, and functional regeneration across various tissues such as skin, bone, nerves, adipose, cartilage, myocardial, neural, skeletal muscle, and bladder. AcD scaffolds enhance differentiation and regeneration by optimizing the cellular microenvironment and activating tissue-specific repair mechanisms. Despite promising results in animal studies, challenges for clinical translation remain, including standardization of preparation protocols and regulation of mechanisms. Future directions involve integrating smart materials and exploring broader medical applications.