Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in the Male

The document from May 1984 discusses Benign Prostatic Hyperplasia (BPH), a condition characterized by the enlargement of the prostate gland in males, and its relationship with androgen metabolism. The article suggests that BPH may be a disorder of androgen metabolism, particularly involving the metabolism of testosterone and dihydrotestosterone (DHT). The paper references various studies that have explored the conversion of testosterone to DHT within the prostate, the role of androgen receptors, and the effects of androgens on gene transcription in the prostate. It also considers the alterations in androgen metabolism that occur with aging and their potential implications for the development of BPH. The document indicates that the research was supported by an NIH grant and includes an up-to-date addendum to the original article first published in the American Journal of Nephrology in 1982. The summary of the document does not provide specific numbers of participants in the studies referenced, as it appears to be a review of multiple studies rather than a report on a single study.