Baricitinib in the Management of Severe Alopecia Areata: A Report of Two Cases with Sustained Clinical Response

    October 2025 in “ Cureus ”
    Youssef Zemmez, Mohamed-amine Ennaciri, Rachid Frikh, Naoufal Hjira
    Studysummary In this study, baricitinib treatment for severe alopecia areata was associated with complete hair regrowth after 12 months in two patients, suggesting it may be an effective alternative to traditional therapies, although safety and clinical implications need careful consideration.
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    Research cited in this study 9

    1. From Mechanisms to Therapies: Current Advances and Breakthroughs in Alopecia Areata Immunopathology Frontiers in Immunology · 2025
    2. Modern and Promising Strategies for Treatment of Alopecia in the United States: Clinical, Pharmacological, Marketing, Regulatory, SWOT Analysis SSP Modern Pharmacy and Medicine · 2025
    3. Long-Term Real-World Outcomes of Baricitinib in Severe Alopecia Areata: A 104-Week Retrospective Analysis From a Single Institute The Journal of Dermatology · 2025
    4. Strong Efficacy of Ritlecitinib 50 mg and Baricitinib 4 mg in Alopecia Areata, but Further Research Needed to Establish Superiority Journal of the European Academy of Dermatology and Venereology · 2025
    5. Baricitinib for the Treatment of Severe Alopecia Areata: Results from a 52-Week Multicenter Retrospective Real-World Study Journal of Dermatological Treatment · 2025
    6. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    7. Alopecia Areata: An Updated Review for 2023 Journal of Cutaneous Medicine and Surgery · 2023
    8. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    9. Alopecia Areata: Current Situation and Perspectives Archivos Argentinos De Pediatria · 2017