Influence of Antiplatelet Therapy with P2Y12 Receptor Inhibitors on Platelet Function in Elderly Patients with Acute Coronary Syndrome
May 2024
in “
International journal of medicine and psychology.
”
Studysummary This study found that elderly patients with acute coronary syndrome had higher PRU rates, and ticagrelor showed greater antiplatelet efficacy compared to clopidogrel in this population. Our plain-language summary of this paper — not a Tressless recommendation.
The study analyzed the effects of P2Y12 receptor inhibitors on platelet aggregation in elderly patients (75-90 years) with acute coronary syndrome, comparing clopidogrel and ticagrelor. On the 2nd day of therapy, the clopidogrel subgroup showed a higher PRU (186.9) compared to the control group (93.2), while the ticagrelor subgroup had a PRU of 74.6, higher than the control (39.3). The study found that older age was linked to higher PRU rates, and ticagrelor demonstrated greater antiplatelet efficacy than clopidogrel.
