Influence of Antiplatelet Therapy with P2Y12 Receptor Inhibitors on Platelet Function in Elderly Patients with Acute Coronary Syndrome

The study analyzed the effects of P2Y12 receptor inhibitors on platelet aggregation in elderly patients (75-90 years) with acute coronary syndrome, comparing clopidogrel and ticagrelor. On the 2nd day of therapy, the clopidogrel subgroup showed a higher PRU (186.9) compared to the control group (93.2), while the ticagrelor subgroup had a PRU of 74.6, higher than the control (39.3). The study found that older age was linked to higher PRU rates, and ticagrelor demonstrated greater antiplatelet efficacy than clopidogrel.