Antibacterial and Cytotoxicity Effects of Aloe Vera Leaves Extract Gel and Zinc Oxide Nanoparticles on Bacterial Skin Infections

    September 2025 in “ Al-Nahrain Journal of Science ”
    Noor Ahmed Kshash, Ali Shehab Ahmed
    The study investigated the antibacterial and cytotoxic effects of green synthesized zinc oxide nanoparticles (GS-ZnONPs) using Aloe vera leaves extract on bacterial skin infections, specifically targeting Staphylococcus spp. isolated from alopecia patients. The GS-ZnONPs demonstrated effective antibacterial activity with minimum inhibitory concentrations (MIC) ranging from 0.400 to 0.650 mg/mL against the bacterial isolates. However, at a concentration of 400 mg/mL, the GS-ZnONPs also exhibited cytotoxic effects on normal human dermal fibroblast cells, reducing cell viability significantly compared to the control group. The findings suggest that while GS-ZnONPs have potential as antibacterial agents, their cytotoxicity at higher concentrations needs careful consideration.
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