Androgenetic Alopecia: In Vivo Models
October 1999
in “Experimental and Molecular Pathology”
TLDR Stump-tailed macaque best for researching hair loss causes and treatments.
This document explores various in vivo models for studying androgenetic alopecia, including rodent models, human skin grafts to mice, and the stump-tailed macaque. The stump-tailed macaque is the most commonly used and useful model. These models offer opportunities for researching the causes and treatment of this type of hair loss. The paper also discusses the use of animal models to study and test new therapies for androgenetic alopecia.
View this study on sciencedirect.com →
Cited in this study
research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts
Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.
research Comparison of Alopecia areata in Human and Nonhuman Mammalian Species
The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.
research Hair problems in women
Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque1
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research The importance of adequate serum ferritin levels during oral cyproterone acetate and ethinyl oestradiol treatment of diffuse androgen-dependent alopecia in women
Having enough iron improves the effectiveness of a specific hair loss treatment in women.
research Reduced Linear Hair Growth Rates of Vellus and of Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice
research Biochemical and trichological characterization of diffuse alopecia in women
Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.
research The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque
Diazoxide applied to the skin can increase hair growth without harmful side effects.
research Animal models of androgen-dependent disorders of the pilosebaceous apparatus
Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
research The effect of testosterone, cyproterone acetate, and minoxidil on hair loss in the androchronogenetic alopecia mouse
The mouse model could be useful for baldness research and testing treatments like testosterone, cyproterone acetate, and minoxidil.
research Action of topical minoxidil in the bald stump-tailed macaque
Minoxidil promotes hair growth but stops working when discontinued.
Related
research Androgenetic Alopecia: In Vivo Models
Stump-tailed macaque best for researching hair loss causes and treatments.