Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone
March 2012
in “Molecular Medicine Reports”
TLDR DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.
The study analyzed the impact of 5α-dihydrotestosterone (DHT) on normal human dermal papilla cells (nHDPCs), discovering that DHT treatment led to decreased cell growth, cell death, G2 cell cycle arrest, increased reactive oxygen species (ROS) production, and senescence. It was found that 61 microRNAs (miRNAs) were significantly affected, with 55 being upregulated and 6 downregulated. The altered miRNAs included miRNA-125a-3p and miR-485-5p, which are known to repress cell proliferation and migration. These changes in miRNA expression suggest potential mechanisms for the effects of DHT on nHDPCs, which may contribute to the development of androgenetic alopecia. The study provided evidence that miRNA regulation is involved in the cellular response to DHT treatment in hair follicle cells.
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