Alopecia Universalis in a Child with Good Response to Combination Therapy: A Case Report
September 2022
in “
Intisasi sains media
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alopecia universalis minoxidil mometasone triamcinolone excimer laser therapy prostaglandin anagen phase corticosteroids immunosuppressants T cell T lymphocyte perifollicular inflammation hair follicle terminal hair vellus hair Severity of Alopecia Tool Score SALT Rogaine laser therapy hair growth phase immune suppression hair inflammation hair follicle damage hair regrowth alopecia severity score
TLDR A young child with complete hair loss improved significantly with a combination of hair growth treatments and laser therapy.
A 22-month-old female patient with alopecia universalis, characterized by complete loss of hair on the head, eyebrows, and eyelashes since 8 months of age, showed significant improvement following a combination therapy. The treatment included 5% minoxidil, 0.1% mometasone, 12 mg triamcinolone, and excimer laser therapy. Minoxidil is known to increase prostaglandin production and maintain the anagen phase of hair growth, while corticosteroids like mometasone and triamcinolone act as immunosuppressants to reduce T cell attacks on hair follicles. The excimer laser therapy contributes by decreasing T lymphocyte proliferation, thus reducing perifollicular inflammation and hair follicle damage. After 4 months of treatment, there was noticeable growth of terminal and vellus hair on the scalp, eyebrows, and eyelashes, and an improvement in nail conditions, with the Severity of Alopecia Tool Score (SALT) decreasing from 100% to 58%. No side effects or recurrences were observed during the treatment period.
