TLDR ATR-FTIR spectroscopy could help monitor alopecia areata treatment response non-invasively.
This study explored the use of ATR-FTIR spectroscopy combined with machine learning to monitor treatment response in alopecia areata patients. Serum samples from 42 patients and 41 healthy donors were analyzed, revealing significant spectral differences in key biochemical regions. The logistic regression model effectively distinguished patients from controls with an AUC of 0.85, sensitivity of 0.89, and specificity of 0.71. It also showed potential in predicting treatment response, with an AUC of 0.86. The findings suggest that this technique could serve as a rapid, non-invasive tool for developing objective biomarkers in autoimmune dermatology, though further multi-center trials are needed for validation.
January 2024 in “JEADV clinical practice” The study helps doctors use patient images to understand and apply SALT scores for treating severe alopecia areata.
4 citations
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April 2023 in “Autoimmunity reviews” High levels of IL6 and CRP, and low levels of vitamin D, might be indicators of alopecia areata.
56 citations
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January 2021 in “Clinical and Experimental Medicine” The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.
144 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.
110 citations
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December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Alopecia areata is a genetic and immune-related hair loss condition that is often associated with other autoimmune diseases and does not typically cause permanent damage to hair follicles.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
