Circumscribed Alopecia Areata Incognita and Response to Tofacitinib

September 2024 in “ Skin Appendage Disorders ”

Mayra A. Reyes‐Soto, Rodrigo Pirmez

circumscribed alopecia areata incognita AAI tofacitinib corticosteroids steroid treatments alopecia areata Xeljanz steroids

From the encyclopedia

Tofacitinib →

a JAK inhibitor for alopecia areata and other autoimmune conditions

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This case report describes a 21-year-old woman with circumscribed alopecia areata incognita, who experienced a sustained positive response to treatment with oral tofacitinib after conventional treatments frequently failed to provide lasting effects. Our plain-language summary of this paper — not a Tressless recommendation.

A 21-year-old woman with circumscribed alopecia areata incognita (AAI) experienced frequent relapses and side effects from conventional steroid treatments. She was treated with oral tofacitinib 5 mg twice daily, resulting in complete hair regrowth after 6 months and no relapses over 10 months. This case suggests that tofacitinib may be an effective alternative for AAI patients who do not respond to corticosteroids.

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Research cited in this study

6 / 6 results

research Disorders of Hair Growth and the Pilosebaceous Unit: Facts and Controversies

4 citations , October 2013 in “Clinics in Dermatology”

This article discusses three controversial hair growth disorders but reports no new research findings; it explores alopecia areata incognita, pseudopelade of Brocq, and psoriasis-linked alopecia.

research Circumscribed Alopecia Areata Incognita

8 citations , June 2012 in “Australasian Journal of Dermatology”

In this study, two patients with localized hair thinning showed histopathological signs typical of alopecia areata, responding to corticosteroid treatment similarly to classical cases.

research Alopecia Areata Incognita: A Case Report

19 citations , January 2011 in “Clinics”

This article reviews alopecia areata incognita, a rare condition mostly seen in young women, and discusses its similarities and differences with telogen effluvium; however, it reports no new clinical findings.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

research Alopecia Areata Incognita: A Hypothesis

60 citations , October 2009 in “Dermatology”

This article proposes a hypothesis for alopecia areata hair loss patterns and provides epidemiological evidence supporting distinct hair loss characteristics between general cases and those with androgenetic alopecia; it presents no new clinical results.

research The Role of Scalp Dermoscopy in the Diagnosis of Alopecia Areata Incognita

150 citations , April 2008 in “Journal of The American Academy of Dermatology”

This study found that videodermoscopy reveals distinct dermoscopic features in patients with alopecia areata incognita, aiding in biopsy decisions by identifying the appropriate sampling area and potentially avoiding unnecessary procedures.