Alopecia Areata as an Immune-Related Adverse Event Associated with Response to Immune Checkpoint Inhibitors

July 2022 in “ European Journal of Dermatology ”

Rika Suzuki, Yukiko Kiniwa, Toshikazu Omodaka, Shiho Katsuie, Tatsuya Nihei, Ai Sato, Yuko Takazawa, Ryuhei Okuyama

alopecia areata immune checkpoint inhibitors brodalumab ustekinumab psoriasis PASI scores AMAGINE-2 AMAGINE-3

Studysummary In this study, researchers using multistate modeling reported that patients with psoriasis treated with brodalumab had a higher probability of achieving and maintaining a therapeutic response compared to those treated with ustekinumab over 52 weeks, based on absolute PASI measurements.

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The study analyzed the effectiveness of brodalumab versus ustekinumab in treating psoriasis using absolute PASI scores. Data from the Phase III AMAGINE-2 and -3 trials showed that over 52 weeks, a higher proportion of patients achieved lower absolute PASI scores with brodalumab compared to ustekinumab. The probability of achieving a response state was significantly greater with brodalumab (hazard ratio: 1.96), and at Week 52, 81% of patients on brodalumab were in response compared to 60% on ustekinumab. Additionally, the mean time in response was longer for brodalumab (215 days) than for ustekinumab (145 days), indicating brodalumab's superior efficacy in maintaining a response.

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