All Subcomponents of the Cutaneous Lupus Erythematosus Disease Area and Severity Index–Activity (CLASI-A) Are Relevant to Identify and Detect Changes in Skin Activity

March 2026 in “ SKIN The Journal of Cutaneous Medicine ”

Victoria P Werth, Joseph F Merola, Q. Li, W. Yang, Catherine Barbey

cutaneous lupus erythematosus litifilimab CLASI-A erythema scale/hypertrophy mucous membrane lesions recent hair loss non-scarring alopecia

TLDR All parts of the CLASI-A score are important for assessing skin activity in cutaneous lupus erythematosus.

The Phase 2 LILAC study (N=132) demonstrated the efficacy of litifilimab in reducing disease activity in patients with active cutaneous lupus erythematosus (CLE), as measured by the CLASI-A score, which evaluates five clinical subcomponents: Erythema, Scale/Hypertrophy, Mucous Membrane Lesions, Recent Hair Loss, and Non-scarring Alopecia. Significant improvements were observed at Week 16, particularly in sunlight-exposed areas, with up to 33.3% of participants showing a 1-point improvement in Erythema. The study confirmed that no single subcomponent solely drives the CLASI-A score, highlighting the importance of all subcomponents in assessing CLE disease activity.

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