Development of the CLASI as an Outcome Instrument for Cutaneous Lupus Erythematosus

March 2007 in “ Dermatologic Therapy ”

Joerg Albrecht, Victoria P. Werth

cutaneous lupus erythematosus CLASI erythema scale hypertrophy mucous membrane involvement acute hair loss dyspigmentation scarring alopecia CLE skin redness skin scaling skin thickening mucous membrane issues hair loss skin discoloration scarring hair loss

TLDR The CLASI is a reliable tool for measuring the severity of cutaneous lupus erythematosus.

In 2007, Albrecht and Werth introduced the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) to address the need for a standardized outcome instrument for assessing cutaneous lupus erythematosus (CLE). The CLASI, which measures both disease activity and damage, includes assessments of various skin and hair symptoms, such as erythema, scale/hypertrophy, mucous membrane involvement, acute hair loss, dyspigmentation, and scarring alopecia. It was validated with the help of experienced dermatologists and showed excellent inter- and intrarater reliability. A clinical study with nine CLE patients demonstrated the CLASI's responsiveness, with activity score changes aligning with physicians' and patients' assessments. The development of the CLASI aimed to improve clinical research in dermatology by providing a reliable tool to quantify disease burden and improvement, and the authors encouraged the creation of similar instruments for other dermatologic conditions.

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