Alefacept for Severe Alopecia Areata: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Clinical Trial

    November 2009 in “ Archives of dermatology ”
    Bruce Strober, Kavita Menon, Amy Mcmichael, Maria Hordinsky, Gerald G. Krueger, Jackie Panko, Kimberly Siu, Jonathan L. Lustgarten, Elizabeth K. Ross, Jerry Shapiro
    TLDR Alefacept does not effectively treat severe alopecia areata.
    A multicenter, double-blind, randomized, placebo-controlled clinical trial involving 45 individuals with severe alopecia areata (AA) assessed the efficacy of alefacept, a T-cell biologic inhibitor. Participants received alefacept for 12 weeks, but results showed no statistically significant improvement in the Severity of Alopecia Tool (SALT) score compared to the placebo group (P = .70). The study concluded that alefacept was ineffective for treating severe AA.
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