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    Glossary Alefacept

    biologic drug that targets T-cells in autoimmune conditions

    Alefacept is a biologic medication that was used to treat moderate to severe plaque psoriasis, an autoimmune skin condition. It works by targeting and reducing the activity of specific immune cells (T-cells) that are involved in the inflammatory process of psoriasis. Although it was effective for some patients, it has been discontinued in many markets due to the availability of newer treatments.

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    Research

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      Treatment of Generalized Lichen Planus With Alefacept

      research Treatment of Generalized Lichen Planus With Alefacept

      52 citations , February 2006 in “Archives of Dermatology”
      This case report describes a 25-year-old woman with widespread lichen planus who did not respond to multiple systemic treatments, including antihistamines, hydroxychloroquine sulfate, and corticosteroids.

      research Alefacept for Severe Alopecia Areata

      43 citations , November 2009 in “Archives of dermatology”
      This study found that alefacept showed no significant improvement in treating severe alopecia areata compared to placebo over a 24-week period.
      Alefacept for Alopecia Areata

      research Alefacept for Alopecia Areata

      33 citations , December 2005 in “Archives of dermatology”
      This study presents case reports of four patients with alopecia areata or alopecia universalis, highlighting varied responses to treatments like prednisone, intralesional triamcinolone, and squaric acid dibutyl ester.
      Systemic Treatments for Alopecia Areata: A Systematic Review

      research Systemic treatments for alopecia areata: A systematic review

      41 citations , September 2018 in “Australasian journal of dermatology”
      This review suggests that oral prednisolone pulse therapy and oral inosiplex may be effective for alopecia areata, but robust evidence from randomized controlled trials is lacking, highlighting the need for better-designed future studies.