Age-Related Changes in the Dorsal Skin Histology in Mini and Wistar Rats

    April 2002 in “ PubMed ”
    Aya Ikawa, Yoshiyuki Ishii, Kazuhiko Suzuki, Akira Yasoshima, Nao Suzuki, Hiroyuki Nakayama, Shunya Takahashi, Kazuteru Doi
    TLDR Mini rats have thinner skin, more fat, and different hair cycles than Wistar rats due to lower growth hormone levels.
    This study compared age-related changes in dorsal skin histology between Mini rats (MRs) with suppressed growth hormone (GH) expression and Wistar rats (WRs). MRs exhibited thinner skin with less collagen, more subcutaneous adipose tissue, and smaller sebaceous glands compared to WRs. Notably, the hair cycle differed significantly; MRs entered a prolonged telogen phase after two 4-week cycles, while WRs began a third cycle. The difference in hair cycle patterns may be linked to lower serum insulin-like growth factor (IGF)-1 levels in MRs, despite similar IGF-1 and IGF-1 receptor mRNA levels in skin tissues. MRs were considered a valuable model for studying dermatopathy related to GH deficiency and understanding GH's effects on skin and hair follicle development.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community What's up with everyone microneedling 1.5 mm per week?

      in Microneedling  52 upvotes 2 years ago
      The conversation is about microneedling for hair loss. The conclusion is that there are differing opinions on the depth and frequency of microneedling, with some studies suggesting positive results with 1.5mm depth once a week, while others prefer lower depths and less frequent sessions.

      community M26 - 9 months after hair transplant! AMA

      in Transplants  624 upvotes 6 years ago
      A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community What happened to that guy who’s been drinking topical minoxidil?!

      in Chat  217 upvotes 1 year ago
      A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

      community Embraced baldness. Time to leave this subreddit

      in Chat  870 upvotes 1 year ago
      A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

    Similar Research

    5 / 1000+ results