Recent Advances on the Mechanisms of Kidney Stone Formation

June 2021 in “ International Journal of Molecular Medicine ”

Zhu Wang, Ying Zhang, Jianwen Zhang, Qiong Deng, Hui Liang

Studysummary This review discusses five potential mechanisms for kidney stone formation, including urinary supersaturation, Randall's plaques, sex hormones, the microbiome, and immune responses, and reports no new results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review discussed the unclear mechanisms of kidney stone formation, highlighting five main mechanisms: urinary supersaturation and crystallization, Randall's plaques as origins of calcium oxalate stones, the role of sex hormones, the impact of the microbiome, and the immune response, particularly macrophage differentiation. These insights aimed to guide future research and improve understanding for medical professionals.

View this study on spandidos-publications.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research The Clinical Applications of Five-Alpha Reductase Inhibitors

2 citations , April 2021 in “Canadian Journal of Urology”

This review summarizes existing studies on 5-alpha reductase inhibitors, noting their effectiveness in reducing prostate volume and cancer risk but highlighting an increased risk of higher grade prostate cancer.

research Protective Effects of Finasteride Against Testosterone-Induced Calcium Oxalate Crystallization and Crystal-Cell Adhesion

15 citations , July 2019 in “Journal of Biological Inorganic Chemistry”

This study found that finasteride effectively prevented testosterone-induced kidney stone formation in renal tubular cells by reducing COM crystal adhesion and crystallization.

research Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride

13 citations , September 2018 in “Dermatologic Therapy”

This study reports that while topical minoxidil treatment showed a response in less than 40% of men after 24 weeks, oral finasteride stopped hair loss in over 80% of patients at 12 months; perceived sexual side effects of the latter may limit its use.