Relationship Between Serum Testosterone Levels and Kidney Stones Prevalence in Men

The study analyzed data from 6,633 male participants and found that lower serum testosterone levels were associated with a higher prevalence of kidney stones, particularly in men aged 41–60. Higher testosterone levels (360–422 ng/dl) were linked to a decreased risk of kidney stones in this age group, suggesting a protective effect. No significant correlation was observed in men aged 20–40, and the results varied for those aged 61–80. The study was limited by its observational nature, indicating correlation rather than causation, and it challenged the view that testosterone promotes stone formation, calling for further research on testosterone's role in metabolism and kidney stone development.